Unveiling NAD's Influence on Brain Health: Energizing Cognitive Vitality
The brain's vitality relies on continuous energy, wherein nicotinamide adenine dinucleotide (NAD) plays a pivotal role. Elevated NAD levels support energy production, safeguard cells, aid cognitive function, and bolster overall brain wellness. NAD is crucial for many key cellular functions below are some of the many cellular functions influenced by NAD.
Energy Boost: NAD's involvement in converting nutrients to ATP sustains optimal brain function, fostering mental clarity and energy metabolism.
Neuroprotection: NAD acts as a shield for brain cells, activating repair mechanisms, combating oxidative stress, and preserving cellular integrity.
Cognitive Enhancement: Improved memory, learning, and attention result from heightened NAD levels, supporting cognitive performance and brain health.
Neurotransmitter Regulation: NAD's role in neurotransmitter synthesis influences mood, stress management, and mental well-being.
Mitochondrial Support: Vital for brain cell function, NAD sustains mitochondrial health, contributing to overall brain vitality.
Neurodegenerative Diseases: Declining NAD levels in diseases like Alzheimer's and Parkinson's necessitate preserving levels for potential therapeutic benefits.
Mood & Mental Wellness: NAD positively impacts mood, potentially alleviating symptoms of depression, anxiety, and enhancing emotional well-being.
Neurogenesis Boost: NAD stimulates neurogenesis, aiding brain repair in conditions involving cell loss, fostering recovery.
Understanding NAD's pivotal role prompts exploring methods like supplementation and lifestyle changes to boost NAD levels, promoting optimal brain function. Prioritize consultation with healthcare professionals before adopting any NAD-related therapies for brain health.
References:
Belenky, P., & Bogan, K. L. (2015). NAD+ metabolism in health and disease. Trends in biochemical sciences, 40(6), 324-331.
Guarente, L. (2014). Aging, metabolism, and cancer. Science, 345(6196), 1189-1190.
Hou, Y., Lautrup, S., Cordonnier, S., Wang, Y., Croteau, D. L., Zavala, E., ... & Bohr, V. A. (2018). NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency. Proceedings of the National Academy of Sciences, 115(8), E1876-E1885.
Wang, S., Li, J., Xie, J., Li, Y., Song, X., Zhang, Y., & Wang, J. (2019). NAD replenishment with nicotinamide mononucleotide protects blood-brain barrier integrity and attenuates cognitive dysfunction in a mouse model of Alzheimer's disease. Aging cell, 18(6), e13017.
Zhang, H., Ryu, D., Wu, Y., Gariani, K., Wang, X., Luan, P., ... & Schadt, E. E. (2016). NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice. Science, 352(6292), 1436-1443.
